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Nah, schizo can really fuck you up, most schizos end up socially isolate and about half of them attempt suicide.
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Dopamine like every other neurotransmitter needs balance, excess is just as harmful as a deficiency of it.
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IQ is so overrated. Sure if you want to stemmaxx it's useful but otherwise it just seems like a fucking burden. Most legit high IQ people i know are "off" in some way and everyone agrees with that assessment.
You don't need a high spatial reasoning ability or whatever to succeed in life. Much rather be pretty or high dopamine.
You don't need a high spatial reasoning ability or whatever to succeed in life. Much rather be pretty or high dopamine.
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OP is definitely one of the best posters here.
boojies
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The dopamine hypothesis of schizophrenia didn't end up panning out so well. Today the NMDAR hypofunction hypothesis has attracted the most interest.
Beyond the Dopamine Hypothesis to the NMDA Glutamate Receptor Hypofunction Hypothesis of Schizophrenia | CNS Spectrums | Cambridge Core
Beyond the Dopamine Hypothesis to the NMDA Glutamate Receptor Hypofunction Hypothesis of Schizophrenia - Volume 12 Issue 4 - Stephen M. Stahl
www.cambridge.org
I only started studying matters after research had progressed to largely rejecting the dopamine hypothesis and had started focusing on the NMDAR hypofunction hypothesis though, so I am not that familiar with the more classical research.
Last edited:
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true, but it's not like dopamine doesn't cause a lot of the positive symptoms, it's just that glutamatergic and dopaminergic systems are related, with the glutamatergic/nmda dysfunction being closer to the root of the issue in schizophrenia; dopaminergic stimulants alone can definitely still cause psychosis, so oldmate above is right in essence that too much dopamine will make you batshit crazy ie. a gigachadThe dopamine hypothesis of schizophrenia didn't end up panning out so well. Today the NMDAR hypofunction hypothesis has attracted the most interest.
Beyond the Dopamine Hypothesis to the NMDA Glutamate Receptor Hypofunction Hypothesis of Schizophrenia | CNS Spectrums | Cambridge Core
Beyond the Dopamine Hypothesis to the NMDA Glutamate Receptor Hypofunction Hypothesis of Schizophrenia - Volume 12 Issue 4 - Stephen M. Stahl
I only started studying matters after research had progressed to largely rejecting the dopamine hypothesis and had started focusing on the NMDAR hypofunction hypothesis though, so I am not that familiar with the more classical research.
albert_camus
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cabergoline?
boojies
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I suppose they do use dopamine antagonists for treating schizophrenia, so that indicates that the people prescribing such things for schizophrenia still have some degree of belief in the dopamine hypothesis. It could just take decades for the old wisdom to work its way through our society though -- hard to say. There is a lot of old research in support of the dopamine hypothesis, but before that I think it was the serotonin hypothesis. Then again
en.wikipedia.org
www.ncbi.nlm.nih.gov
www.sciencedirect.com
Risperidone - Wikipedia
en.wikipedia.org
they still do treat it with inverse serotonin agonists / serotonin antagonists, which would just as much so indicate a potential continued adherence to the serotonergic hypothesis of schizophrenia. The modern treatments -- last I knew -- was going through clinical trials still, and they are NMDAR positive allosteric modulators, which indicates a coming around to the NMDAR hypofunction hypothesis. How discouraging that the history of schizophrenia treatment has been one of consistent hope and disappointment.
The 5-HT hypothesis of schizophrenia - PubMed
Schizophrenia is a serious psychiatric illness that is responsible for a substantial proportion of mental illness worldwide. Symptoms include hallucination, delusions, thought disorder and negative symptoms, including poverty of thought and emotion, and social withdrawal. Early theories of...
www.ncbi.nlm.nih.gov
https://www.cell.com/fulltext/S0896-6273(03)00757-8
Glutamate modulators for treatment of schizophrenia
Over the past two decades, accumulating evidence has implicated the role of glutamatergic dysfunction in the pathophysiology of schizophrenia. There h…
www.sciencedirect.com
The heterogeneity of results isn't that surprising to me. Schizophrenia is thought today to be a set of phenotypes, each of which having an autistic inversion. As a set of distinct phenotypes, it's pretty much tautological that it is a heterogeneous condition.
Those are both neurological presentations associated with schizophrenia; however, they are not equivalent. The breakdown of the default mode network is associated with clinical insight deficits; the reduced volume of the vlpfc with cognitive insight deficits.
I would only expect the NMDAR PAMs to work in cases with diminished vlPFC volume, for they essentially will serve to strengthen one of the primary functions of the vlPFC -- maintaining activation of the task positive network despite emotional distractions in the environment.
In schizophrenia with normal vlPFC volume but lesioning of the default mode network, I wouldn't expect improvement from NMDAR PAMs.
I would expect that group of schizophrenics -- with diminished deactivation of the default mode network during working memory task -- to be the one that benefited from the NMDAR positive allosteric modulators.
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itsoverkillyourself
half vietnamese dark triad badboy
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if you dont take caber...you are not even trying
- owers cortisol and prolactin -makes you low inhib -influence your dopamin system in a positive way -lowers bodyfat while maintaining muscles -strengthens errections -gives you the ability to cum twice/threetimes without any pause -fights depression caber is the key to the life you ever...
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what i meant is that i was under the impression that nmdar hypofunction causes the positive symptoms mostly because nmdar regulates dopamine function (hence dopaminergic drugs coming with a risk of psychosis), and that in that sense the two theories are more complimentary than exclusive, and afaik clozapine et al does generally work well for positive symptoms, the reason they aren't great for clinical outcomes is because they make the negative symptoms (ie. laziness, anhedonia, braindeadness) worse, just ask mvp, he's living that reality right nowI suppose they do use dopamine antagonists for treating schizophrenia, so that indicates that the people prescribing such things for schizophrenia still have some degree of belief in the dopamine hypothesis. It could just take decades for the old wisdom to work its way through our society though -- hard to say. There is a lot of old research in support of the dopamine hypothesis, but before that I think it was the serotonin hypothesis. Then again
Risperidone - Wikipedia
they still do treat it with inverse serotonin agonists / serotonin antagonists, which would just as much so indicate a potential continued adherence to the serotonergic hypothesis of schizophrenia. The modern treatments -- last I knew -- was going through clinical trials still, and they are NMDAR positive allosteric modulators, which indicates a coming around to the NMDAR hypofunction hypothesis. How discouraging that the history of schizophrenia treatment has been one of consistent hope and disappointment.
The 5-HT hypothesis of schizophrenia - PubMed
Schizophrenia is a serious psychiatric illness that is responsible for a substantial proportion of mental illness worldwide. Symptoms include hallucination, delusions, thought disorder and negative symptoms, including poverty of thought and emotion, and social withdrawal. Early theories of...
https://www.cell.com/fulltext/S0896-6273(03)00757-8
Glutamate modulators for treatment of schizophrenia
Over the past two decades, accumulating evidence has implicated the role of glutamatergic dysfunction in the pathophysiology of schizophrenia. There h…
The heterogeneity of results isn't that surprising to me. Schizophrenia is thought today to be a set of phenotypes, each of which having an autistic inversion. As a set of distinct phenotypes, it's pretty much tautological that it is a heterogeneous condition.
Those are both neurological presentations associated with schizophrenia; however, they are not equivalent. The breakdown of the default mode network is associated with clinical insight deficits; the reduced volume of the vlpfc with cognitive insight deficits.
I would only expect the NMDAR PAMs to work in cases with diminished vlPFC volume, for they essentially will serve to strengthen one of the primary functions of the vlPFC -- maintaining activation of the task positive network despite emotional distractions in the environment.
In schizophrenia with normal vlPFC volume but lesioning of the default mode network, I wouldn't expect improvement from NMDAR PAMs.
I would expect that group of schizophrenics -- with diminished deactivation of the default mode network during working memory task -- to be the one that benefited from the NMDAR positive allosteric modulators.
but maybe im wrong, idk, i'll defer to you since understanding the schizo brain is one of your life missions
boojies
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One thing to keep in mind is that psychosis is a symptom; conversely, schizophrenia is a condition that presents with psychosis. I'm not very familiar with the dopamine mechanism for psychosis, but amphetamine increase synaptic dopamine (as a dopamine releasing agent, it causes the synaptic vesicle of a dopamine neuron to release its neurotransmitter into the synapse).
link.springer.com
www.sciencedirect.com
Is a sort of artist's conception I've fashioned.
www.sciencedirect.com
The effect of intrastriatal application of directly and indirectly acting dopamine agonists and antagonists on the in vivo release of acetylcholine measured by brain microdialysis
The effect of intrastriatal application of D-1, D-2 and indirect dopaminergic drugs on the release of striatal acetylcholine as a function of the post-implantation intervals was studied using in vivo microdialysis. The dopamine, D-2 agonists LY 171555 and (−)N0437 inhibited the release of...
link.springer.com
and it is known that it can cause -- at least acute -- psychosis.
However, amphetamine likely causes deactivation of the default mode network,
Task-Positive Network - an overview | ScienceDirect Topics
www.sciencedirect.com
Is a sort of artist's conception I've fashioned.
Neural correlates of insight in dreaming and psychosis
The idea that dreaming can serve as a model for psychosis has a long and honourable tradition, however it is notoriously speculative. Here we demonstr…
www.sciencedirect.com
It's massively complex and hard to think of though. It's hard to reconcile amphetamine inducing a psychosis similar to schizophrenia's with amphetamine (probably) causing diminished activation of the default mode network. I find that it is really cognitively demanding trying to process all of the pertinent information into a coherent whole. There is just such nuance to neuropsychiatry, and so much inversion that it makes my head spin. It's amazing how essentially inverted conditions can both present as one condition (the extreme ends of the autism-psychosis spectrum being two states of catatonia that have been difficult for the researchers to tease apart).
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didnt readOne thing to keep in mind is that psychosis is a symptom; conversely, schizophrenia is a condition that presents with psychosis. I'm not very familiar with the dopamine mechanism for psychosis, but amphetamine increase synaptic dopamine (as a dopamine releasing agent, it causes the synaptic vesicle of a dopamine neuron to release its neurotransmitter into the synapse).
The effect of intrastriatal application of directly and indirectly acting dopamine agonists and antagonists on the in vivo release of acetylcholine measured by brain microdialysis
The effect of intrastriatal application of D-1, D-2 and indirect dopaminergic drugs on the release of striatal acetylcholine as a function of the post-implantation intervals was studied using in vivo microdialysis. The dopamine, D-2 agonists LY 171555 and (−)N0437 inhibited the release of...
and it is known that it can cause -- at least acute -- psychosis.
However, amphetamine likely causes deactivation of the default mode network,
Task-Positive Network - an overview | ScienceDirect Topics
Is a sort of artist's conception I've fashioned.
Neural correlates of insight in dreaming and psychosis
The idea that dreaming can serve as a model for psychosis has a long and honourable tradition, however it is notoriously speculative. Here we demonstr…
It's massively complex and hard to think of though. It's hard to reconcile amphetamine inducing a psychosis similar to schizophrenia's with amphetamine (probably) causing diminished activation of the default mode network. I find that it is really cognitively demanding trying to process all of the pertinent information into a coherent whole. There is just such nuance to neuropsychiatry, and so much inversion that it makes my head spin. It's amazing how essentially inverted conditions can both present as one condition (the extreme ends of the autism-psychosis spectrum being two states of catatonia that have been difficult for the researchers to tease apart).
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LookismUser
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I have IQ in 140’s. The answer is a definite yes.
Studies show the higher your IQ, the higher risks for mental illness, anxiety, and severe depression. Because you can objectively see yourself. Like the saying goes, “you require an immense amount of knowledge just to be able to see your own depth of ignorance.�? This is probably going to be a long and involved answer, so please stick with me.
Your ego is a mask, a story that you tell yourself. But those with high IQ are more easily able to see through the mask, and without some sort of spirituality, there’s nothing underneath. When you see your ego is false, it’s like a mirror looking into a mirror. But the up side is that you can see how your subconscious is programmed and take control of the 95% subconscious actions that we all have.
But because you see right through your ego…you also see straight through everyone else’s! If you’re not careful to agree with the subconscious lies everyone tells themselves, you WILL DEEPLY offend everyone. No one wants to hear that their problems today are the result of their actions and words yesterday, even if it’s as clear as day. They just want to be told they’re unlucky and have no control. You must realize what others want to believe is their life, and it’s not up to you to tell them the truth if they don’t want to see it.
If your IQ is too high for those surrounding you, you WILL be seen as insane, and highly ignorant. Because others don’t understand you, they assume you must be insane. They assume since you tell them stuff against their beliefs that you’re the one who’s ignorant. And they WILL HATE THE HELL OUT OF YOU! Intelligence must be hidden as much as possible for the sanity of the person who holds it. If you’re not careful, you’ll start to believe that you may just be insane and that will lead to many self destructive behaviors and thoughts. You must act dumb in many situations. (Anyone intelligent will see that I am putting a lot of emphasis on this, and usually our actions are the result of strong emotions, therefore I must have been extremely hurt recently or traumatized in the past by this lesson)
You rarely conform to social norms because they’re just stupid and a waste of time. This gets back into the ego I talked about. Almost 95% of our actions every single day are subconscious and random, depend on how society programmed our subconscious to respond to stimuli, and our ego justifies them after we do them in an effort to maintain consistent story. “I must have done that because I felt..�? because few understand this, they think their programmed responses are free will, that they’re making the choice, even though science shows they react before they even have a mental thought. The thought and justification come after, sometimes by several seconds. The justification depends on what they’ve been programmed to believe to conform with their personal narrative. Society is brainwashed into thinking they need all these things to be happy, must be and act certain ways, even if they’re self-destructive. So the higher the IQ, the less you’re usually accepted by society.
The benefits are an insane ability to learn and master anything and pattern recognition. Pattern recognition is our superpower, and it leads us to see that much of society are not conscious. They don’t see that their lives are a reflection of their daily habits. Like going to the gym. They think becoming wealthy is luck, and has nothing to do with their daily learning and work. That’s like thinking someone going to the gym for two years just happened to luck out when they lost 50lbs on the way….They cannot see the correlation between using their turn signals and risks of accidents, or that how they react to others actually affects their lives. They live largely asleep. But when you see those patterns, that the entire universe revolves around magnificent and brilliant patterns, even human psychology, you generally have an extremely easy time manipulating those patterns to gain what you want or to help others. Wealth is easy.
Studies show the higher your IQ, the higher risks for mental illness, anxiety, and severe depression. Because you can objectively see yourself. Like the saying goes, “you require an immense amount of knowledge just to be able to see your own depth of ignorance.�? This is probably going to be a long and involved answer, so please stick with me.
Your ego is a mask, a story that you tell yourself. But those with high IQ are more easily able to see through the mask, and without some sort of spirituality, there’s nothing underneath. When you see your ego is false, it’s like a mirror looking into a mirror. But the up side is that you can see how your subconscious is programmed and take control of the 95% subconscious actions that we all have.
But because you see right through your ego…you also see straight through everyone else’s! If you’re not careful to agree with the subconscious lies everyone tells themselves, you WILL DEEPLY offend everyone. No one wants to hear that their problems today are the result of their actions and words yesterday, even if it’s as clear as day. They just want to be told they’re unlucky and have no control. You must realize what others want to believe is their life, and it’s not up to you to tell them the truth if they don’t want to see it.
If your IQ is too high for those surrounding you, you WILL be seen as insane, and highly ignorant. Because others don’t understand you, they assume you must be insane. They assume since you tell them stuff against their beliefs that you’re the one who’s ignorant. And they WILL HATE THE HELL OUT OF YOU! Intelligence must be hidden as much as possible for the sanity of the person who holds it. If you’re not careful, you’ll start to believe that you may just be insane and that will lead to many self destructive behaviors and thoughts. You must act dumb in many situations. (Anyone intelligent will see that I am putting a lot of emphasis on this, and usually our actions are the result of strong emotions, therefore I must have been extremely hurt recently or traumatized in the past by this lesson)
You rarely conform to social norms because they’re just stupid and a waste of time. This gets back into the ego I talked about. Almost 95% of our actions every single day are subconscious and random, depend on how society programmed our subconscious to respond to stimuli, and our ego justifies them after we do them in an effort to maintain consistent story. “I must have done that because I felt..�? because few understand this, they think their programmed responses are free will, that they’re making the choice, even though science shows they react before they even have a mental thought. The thought and justification come after, sometimes by several seconds. The justification depends on what they’ve been programmed to believe to conform with their personal narrative. Society is brainwashed into thinking they need all these things to be happy, must be and act certain ways, even if they’re self-destructive. So the higher the IQ, the less you’re usually accepted by society.
The benefits are an insane ability to learn and master anything and pattern recognition. Pattern recognition is our superpower, and it leads us to see that much of society are not conscious. They don’t see that their lives are a reflection of their daily habits. Like going to the gym. They think becoming wealthy is luck, and has nothing to do with their daily learning and work. That’s like thinking someone going to the gym for two years just happened to luck out when they lost 50lbs on the way….They cannot see the correlation between using their turn signals and risks of accidents, or that how they react to others actually affects their lives. They live largely asleep. But when you see those patterns, that the entire universe revolves around magnificent and brilliant patterns, even human psychology, you generally have an extremely easy time manipulating those patterns to gain what you want or to help others. Wealth is easy.
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This thread is flawed. Formative experiences determine your ability to have fun around normies. A lot of people here don't fit in with normies because of years of bad treatment due to our looks.
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I have a 140+ IQ but I'm always depressed and I smoke all the time
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GeniusOne thing to keep in mind is that psychosis is a symptom; conversely, schizophrenia is a condition that presents with psychosis. I'm not very familiar with the dopamine mechanism for psychosis, but amphetamine increase synaptic dopamine (as a dopamine releasing agent, it causes the synaptic vesicle of a dopamine neuron to release its neurotransmitter into the synapse).
The effect of intrastriatal application of directly and indirectly acting dopamine agonists and antagonists on the in vivo release of acetylcholine measured by brain microdialysis
The effect of intrastriatal application of D-1, D-2 and indirect dopaminergic drugs on the release of striatal acetylcholine as a function of the post-implantation intervals was studied using in vivo microdialysis. The dopamine, D-2 agonists LY 171555 and (−)N0437 inhibited the release of...
and it is known that it can cause -- at least acute -- psychosis.
However, amphetamine likely causes deactivation of the default mode network,
Task-Positive Network - an overview | ScienceDirect Topics
Is a sort of artist's conception I've fashioned.
Neural correlates of insight in dreaming and psychosis
The idea that dreaming can serve as a model for psychosis has a long and honourable tradition, however it is notoriously speculative. Here we demonstr…
It's massively complex and hard to think of though. It's hard to reconcile amphetamine inducing a psychosis similar to schizophrenia's with amphetamine (probably) causing diminished activation of the default mode network. I find that it is really cognitively demanding trying to process all of the pertinent information into a coherent whole. There is just such nuance to neuropsychiatry, and so much inversion that it makes my head spin. It's amazing how essentially inverted conditions can both present as one condition (the extreme ends of the autism-psychosis spectrum being two states of catatonia that have been difficult for the researchers to tease apart).
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Isn't this the majority of the losers who follow Aaron Clareys videos lol. A few select of my friends approach life in this way and it is getting them places. Having the motive and drive to constantly achieve new things is something a few people actually have. Most people just want to sit on their asses and complain about shit all day because their dopamine is fucked. Its the same with alcoholics, the same reason alcoholics always turn back to drink is because of the rewarding feeling they get from booz however people who do this via dopamine are succesful
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Another twat who thinks hes smarter than he is blaming others for his downfalls. Delusional confirmed.