Low protein high carb decreases D2 dopamine receptor density

Anakind

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http://www.ncbi.nlm.nih.gov/pubmed/1349715

A low protein-high carbohydrate diet decreases D2 dopamine receptor density in rat brain.

Abstract

The property of D2 dopamine receptors in the rat brain was evaluated after long-term dietary manipulation. Groups of rats were pair-fed with equicaloric diet containing low protein (8%)-high carbohydrate, high protein (52%)-low carbohydrate and normal protein (20%) for 36 weeks. The low protein-high carbohydrate fed rats exhibited a significant decrease in the density (Bmax) of D2 dopamine receptor in the striatum (28%) and the mesolimbic regions (36%) with no apparent change in the receptor affinity (Kd). These findings suggest that long-term consumption of a low protein-high carbohydrate diet, by decreasing D2 dopamine receptor density, may be an important determinant of central dopaminergic function.
@"paulus" @"RealRob"
 

paulus

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Anakind said:
http://www.ncbi.nlm.nih.gov/pubmed/1349715

A low protein-high carbohydrate diet decreases D2 dopamine receptor density in rat brain.

Abstract

The property of D2 dopamine receptors in the rat brain was evaluated after long-term dietary manipulation. Groups of rats were pair-fed with equicaloric diet containing low protein (8%)-high carbohydrate, high protein (52%)-low carbohydrate and normal protein (20%) for 36 weeks. The low protein-high carbohydrate fed rats exhibited a significant decrease in the density (Bmax) of D2 dopamine receptor in the striatum (28%) and the mesolimbic regions (36%) with no apparent change in the receptor affinity (Kd). These findings suggest that long-term consumption of a low protein-high carbohydrate diet, by decreasing D2 dopamine receptor density, may be an important determinant of central dopaminergic function.
@"paulus" @"RealRob"
:banderas:

Stoneage diet is legit
 

Anakind

King of Chads
Joined
Jul 1, 2015
Messages
12,654
Reputation
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Severe Aspie said:
what does that mean?
High doses of glucose (carbohydrates in various forms) lead to constant release of dopamine in your reward circuit. As a result dopamine receptors are down regulated and dopamine is depleted b/c you need amino acids to produce neurotransmitters. It's pretty similar to what constant porn does to your brain b/c it affects the same receptors.
[hr]
igesio said:
Does that mean high carb is good or bad
It's rather bad. The typical results are insulin resistance and diabetes next to addictive behavioral patterns b/c you need more and more sugar to have the same effects in terms of dopamine release.

Just do the experiment and go for a few days with no carbs at all (only eating meat, fish, eggs and nuts) and you will realize how even little things cause you to feel more pleasure. That's b/c it leads to a higher receptor density so your brain is more sensitive to the effects of dopamine as it should be.
 
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