He specifically talks about this in a recent interview for the manson/pumpkins tour. He said he played music because he had trouble socially connecting to people. This is no different than most awkard/incel guys. He found a hobby to dedicate himself to that would distract himself from his isolation.
He is just one of the lucky ones who has been successful as a result of that. For every Manson, there's a thousand brooding teens playing guitar in their bedrooms going nowhere.
Just like for every Mark Zuckerberg, there are a thousand guys coding apps and websites that no one buys or signs up for.
Hitting it huge like that requires the alignment of so many factors that you could easily just call it "luck" and not be too far off.